Gamestop is holding an indie game challenge.
This might be out of 99% of your leagues, but there's a few of you who might be able to participate in this.
Also you or your team could win up to $100,000 as well as have your game published. Other prizes include a $50,000 scholarship to attend the guildhall at SMU.
You can find all the rules and whatnot at http://www.indiegamechallenge.com/